The World Health Organization (WHO) has released a list classifying medically important antimicrobials for human medicine based on their significance and potential risks in non-human sectors. The categorization includes critically important, highly important, and important to human medicine to address the impact on antimicrobial resistance in humans (Source: WHO, Feb. 8, 2024).
Pseudogout and Fracture Risk: Unraveling the Connection to Calcium Pyrophosphate Crystal Arthritis
Presence of pseudogout, or acute calcium pyrophosphate crystal arthritis, has been linked to a doubled risk of fractures compared to those without the disease, with a hazard ratio (HR) of 1.8. Specifically, the risk for wrist fractures increased over threefold with an HR of 3.6 (Source: Arthritis Rheumatology, Jan. 14, 2024).
Supporting Senior Well-being: The Impact of Motivational Calls on Depression and Loneliness
Efforts to support the mental well-being of seniors have shown promise in reducing depression symptoms and alleviating loneliness. Regular weekly telephone calls to older adults aged ≥65 years, providing motivation and support, resulted in immediate benefits in terms of depression severity as early as 1 month, sustaining this positive effect until the primary trial endpoint at 3 months (Source: Lancet Healthy Longevity, Feb. 2024).
CPR Duration and Survival Odds: Insights from a Multicenter Analysis of In-Hospital Cardiac Arrests
An analysis of a large multicenter registry of in-hospital cardiac arrests reveals that longer durations of cardiopulmonary resuscitation (CPR) correspond to decreased chances of survival. The likelihood of survival drops below 10% after 10 minutes, falls to less than 5% after 20 minutes, and is less than 1% after >40 minutes (Source: BMJ, Feb. 7, 2024).
Dementia Prevalence in India: LASI-DAD Study Sheds Light on Neurocognitive Disorders Among Older Adults
Results from the Harmonized Diagnostic Assessment of Dementia for the LASI (LASI-DAD) study indicate a high prevalence of dementia in India among older adults aged ≥60 years. Approximately 24 million older adults have mild neurocognitive disorder, and 9.9 million have major neurocognitive disorder. Prevalence tends to be higher among older individuals, those with lower educational attainment, and illiterate and rural-living older adults (Source: PLoS Medicine, Feb. 7, 2024).
Iron Deficiency in Preterm Infants: Examining the Higher Risk Despite Increased Iron Intake
Infants born very prematurely and not breast milk-fed exhibit a higher prevalence of iron deficiency (36.8%) at 4 to 6 months, despite higher iron intake compared to breast-milk-fed infants (20.6%), with an odds ratio (OR) of 2.25. This elevated risk persists even after adjusting for factors such as maternal age, smoking, and single-parent status (OR 2.11) (Source: Nutrients, Jan. 30, 2024).
Artificial Light and Wet AMD Risk: Understanding the Association from a Korean Study
A recent study from Korea has suggested an association between higher levels of residential outdoor artificial light at nighttime and an increased risk of developing wet age-related macular degeneration (AMD). This risk is more pronounced among people living in urban areas and persists after adjusting for individual- and area-level risk factors (Source: JAMA Network Open, Jan. 2, 2024).
Blood Proteins and Dementia Prediction: UK Biobank Study Identifies Key Markers
Four blood proteins – glial fibrillary acidic protein (GFAP), neurofilament light (NfL), growth differentiation factor-15 (GDF-15), and latent-transforming growth factor beta-binding protein 2 (LTBP2) – in healthy adults from the UK Biobank are associated with the development of all-cause dementia, Alzheimer's disease, or vascular dementia later on (Source: Nature Aging, Feb. 12, 2024).
